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MYP_152459
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Basic Information
Phylloseptin-PBa1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
19 amino acids
C97H155N23O24
Standard
Sequence
FLSLIPHIASGIASLVKNF
Physicochemical Analysis
2027.41 Da
8.76
0.85
0.59
0.0445
1.23
0.53
0.49
17.19
148.95
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
736.81
-4.33
25.0
26.0
64.0
144.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0095392 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa burmeisteri [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli NCTC 10418
200 μM
MIC
PMID30612735 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30612735/
RECORD: Rec_0173437 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa burmeisteri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
The peptide is highly hemolytic
15.8 μM
HC50
PaperPhylloseptin-PBa1, -PBa2, -PBa3: Three Novel Antimicrobial Peptides From the Skin Secretion of Burmeister's Leaf Frog (Phyllomedusa Burmeisteri)
RECORD: Rec_0213610 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa burmeisteri [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus NCTC 10788
5 μM
MIC
PMID30612735 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30612735/
RECORD: Rec_0221723 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa burmeisteri [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Hourse red blood cells
2.0 μM
Hemolysis
PMID30612735 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30612735/
RECORD: Rec_0232120 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID30612735 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30612735/
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