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MYP_152423
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Basic Information
Indolicidin (1-12)[R12P]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
12 amino acids
C93H114N18O13
Standard
Sequence
ILPWKWPWWPWP
Physicochemical Analysis
1692.01 Da
8.75
0.76
0.55
0.0633
-0.54
0.08
0.46
34.07
65.00
0.4167
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
453.23
6.60
15.0
14.0
37.0
124.0
14.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024536 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
180 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0179632 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
80 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0257943 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0366306 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
80 μM
IC50
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0371151 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
180 μM
IC50
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/