Peptide Database

Peptide NameSC19EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC117H177N25O36

DescriptionStandard

        WEEWDKKIEEYTKKIEELI
    

Molecular Weight2509.80 Da

Isoelectric Point (pI)4.55

Net Charge (pH 7.0)-3.23

Net Charge (pH 7.4) -3.45

Charge Density (pH 7.0) -0.1698

GRAVY Index-1.40

Hydrophobic Moment 0.64

Boman Index-0.23

Instability Index81.42

Aliphatic Index 82.11

Aromaticity 0.1579

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1024.34

LogP -2.73

H-bond Donors 35.0

H-bond Acceptors 33.0

Rotatable Bonds 88.0

Heavy Atoms 178.0

Ring Count 5.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317369 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 HXB2:inhibition of cell-cell fusion in TZM-bl cells

Activity0.2172±0.0165 μM

MethodIC50

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0406299 VERIFIED: YES