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MYP_152325
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Basic Information
Leucrocin II
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
10 amino acids
C42H64N12O14
Standard
Sequence
NAGSLLSGWG
Physicochemical Analysis
961.03 Da
5.53
-0.24
-0.44
-0.0240
0.22
0.30
0.39
10.97
88.00
0.1000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
424.56
-5.65
15.0
14.0
29.0
68.0
2.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017488 VERIFIED: YES
Provenance & Taxonomy
Crocodylus siamensis [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus epidermidis
0.66 μg/mL
MIC
PaperCharacterization of the novel antibacterial peptide Leucrocin from crocodile (Crocodylus siamensis) white blood cell extracts.
RECORD: Rec_0030026 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0071792 VERIFIED: YES
Provenance & Taxonomy
Crocodylus siamensis [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Gram-negative S. typhi
0.66 μg/mL
MIC
PaperCharacterization of the novel antibacterial peptide Leucrocin from crocodile (Crocodylus siamensis) white blood cell extracts.
RECORD: Rec_0087179 VERIFIED: YES
Provenance & Taxonomy
Crocodylus siamensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (8% Hemolysis at 3 microg/ml
3 μg/mL
Hemolysis
PMID21184776 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21184776/
RECORD: Rec_0099717 VERIFIED: YES
Provenance & Taxonomy
Crocodylus siamensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Mammalian Cell
Salmonella typhi
0.66 μg/mL
MIC
PMID21184776 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21184776/
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