Peptide Database

Peptide NameSLAY-screened peptide P5457

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H140N30O29S

DescriptionStandard

        SGSFAPSCYSPHYNARKVHN
    

Molecular Weight2222.40 Da

Isoelectric Point (pI)9.19

Net Charge (pH 7.0)1.62

Net Charge (pH 7.4) 1.29

Charge Density (pH 7.0) 0.0811

GRAVY Index-0.91

Hydrophobic Moment 0.41

Boman Index-0.10

Instability Index96.59

Aliphatic Index 24.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 951.48

LogP -12.94

H-bond Donors 34.0

H-bond Acceptors 34.0

Rotatable Bonds 65.0

Heavy Atoms 157.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0352496 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/