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MYP_152309
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Basic Information
7R-Ahx-HBV Large envelope protein (96-116)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
29 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
RRRRRRRXPLSPPLRNTHPQAMQWNSTTF
Physicochemical Analysis
0.00 Da
0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054072 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 8
Bio-Activity Profile
Antiviral
Human hepatocellular carcinoma HepG2
515.9
LC50
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0152396 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 8
Bio-Activity Profile
Antiviral
Hepatitis B virus (HBV)
41.4
EC50
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0193163 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 8 is 6-aminocaproic acid.
Bio-Activity Profile
Antiviral Anti-HBV
HBV
41.4±8.7 μM
EC90
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperArtificial recombinant cell-penetrating peptides interfere with envelopment of hepatitis B virus nucleocapsid and viral production. | Pan XB, Wei L, Han JC, Ma H, Deng K, Cong X. | Antiviral Res. 2011 Jan;89(1):109-14. | DOI:10.1016/j.antiviral.2010.12.001 | PMID:21144865 PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0218823 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 8 is 6-aminocaproic acid
Bio-Activity Profile
Antimicrobial Antiviral
cells
6.5±1.5 μM
EC50
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0267123 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
None
None
Acp: epsilon-aminocaproic acid residue
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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