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MYP_152291
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Basic Information
D-SynB1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C86H146N36O26
Standard
Sequence
RGGRLSYSRRRFSTSTGR
Physicochemical Analysis
2100.30 Da
12.00
5.76
5.55
0.3199
-1.53
0.36
-0.67
81.21
21.67
0.1111
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1071.03
-16.92
44.0
32.0
71.0
148.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039924 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
SynB/Protegrin
9823
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Fluorophore labeling
None
N-term detail: Labelled with NBD; lowercase source residues at positions 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 denote stereochemical modification
Bio-Activity Profile
Cell-penetrating peptide Antimicrobial
K562 cells
Fluorescence-based uptake assay
PMID12783857 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12783857/
RECORD: Rec_0072433 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
SynB
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24903464 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24903464/
RECORD: Rec_0084220 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida glabrata
25 μM
MIC50
PMID28556271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28556271/
RECORD: Rec_0108341 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
50 μM
MIC50
PMID28556271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28556271/
RECORD: Rec_0139989 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Conjugation with NBD
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery Antimicrobial
PMID12783857 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12783857/
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