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MYP_152262
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Basic Information
Antimicrobial peptide AcrAP2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
18 amino acids
C95H148N20O23
Standard
Sequence
FLFSLIPNAISGLLSAFK
Physicochemical Analysis
1938.31 Da
8.75
0.76
0.55
0.0422
1.36
0.49
0.53
-0.51
141.11
0.1667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
679.03
-3.20
23.0
24.0
61.0
138.0
4.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0140582 VERIFIED: YES
Provenance & Taxonomy
Androctonus crassicauda [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Horse red cells
64 μM
Hemolysis
PMID25332684 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25332684/
RECORD: Rec_0258348 VERIFIED: YES
Provenance & Taxonomy
Androctonus crassicauda [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
250 μM
MIC
PMID25332684 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25332684/
RECORD: Rec_0300090 VERIFIED: YES
Provenance & Taxonomy
Androctonus crassicauda [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Staphylococcus aureus
8 μM
MIC
PaperPubMed PMID: 25332684 PMID25332684 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25332684/
RECORD: Rec_0322420 VERIFIED: YES
Provenance & Taxonomy
Androctonus crassicauda [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
16 μM
MIC
PMID25332684 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25332684/
RECORD: Rec_0324446 VERIFIED: YES
Provenance & Taxonomy
Androctonus crassicauda [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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