Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length506 amino acids

Chemical FormulaC2589H3997N641O743S17

DescriptionStandard

        MCTKIIPVLWGCFLLWNLYISSSQTIYPGIKARITQRALDYGVQAGMEMIEQMLKQKNLPDLSGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEFKSPIFQDTGGADLFLSGVYFTGIIILTRNDFGHPILKLQDCYAQVSHAHISFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIANEVEALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLVDPYFSPVPFVLPERSNSMLYIGIAEYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPVINLQPGNFTLDIPASIMMLTQTNNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLTLPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVFEGFLLISTDLKYETSSKQHPSFHGWEGLNLINGWWRGKAP
    

Molecular Weight56535.38 Da

Isoelectric Point (pI)5.28

Net Charge (pH 7.0)-11.71

Net Charge (pH 7.4) -12.56

Charge Density (pH 7.0) -0.0231

GRAVY Index0.15

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index37.55

Aliphatic Index 102.49

Aromaticity 0.1126

Extinction Coeff. Reduced 59820.00

Extinction Coeff. Oxidized 60070.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0324393 VERIFIED: NO

Provenance & Taxonomy

OrganismCebus imitator [Animal]

FamilyBPI

Tax ID9516

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence