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MYP_152212
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Basic Information
Esculentin-2LF1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
37 amino acids
C173H290N50O47S2
Standard
Sequence
GIFSLIKTAAKFVGKNLLKQAGKAGLEHLACKANNQC
Physicochemical Analysis
3886.59 Da
9.79
4.82
4.53
0.1304
0.08
0.64
0.09
8.11
97.84
0.0541
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1588.93
-16.05
55.0
55.0
137.0
272.0
3.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0158662 VERIFIED: YES
Provenance & Taxonomy
Amolops lifanensis [Animal]
Amolopin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial
PaperJ.M. Conlon et al. / Peptides 28 (2007) 1268-1274. Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
RECORD: Rec_0169000 VERIFIED: YES
Provenance & Taxonomy
Amolops lifanensis [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Enterococcus faecalis 981
12.5 μM
MIC
PMID25066917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25066917/
RECORD: Rec_0237125 VERIFIED: YES
Provenance & Taxonomy
Hylarana taipehensis [Animal]
Esculentin
110118
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
31-37
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
E. cloacae CGMCC 1.57
25 μM
MIC
PaperIdentification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus PMID25066917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25066917/
RECORD: Rec_0243012 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0243179 VERIFIED: YES
Provenance & Taxonomy
Amolops lifanensis [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Nocardia asteroides 201118
3.1 μM
MIC
PMID25066917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25066917/
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