Peptide Database

Peptide Namegrowth/differentiation factor-10

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length110 amino acids

Chemical FormulaC555H861N149O156S10

DescriptionStandard

        QWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR
    

Molecular Weight12437.33 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.21

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0019

GRAVY Index-0.04

Hydrophobic Moment 0.61

Boman Index0.06

Instability Index41.11

Aliphatic Index 85.00

Aromaticity 0.1000

Extinction Coeff. Reduced 22460.00

Extinction Coeff. Oxidized 22835.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4842.08

LogP -41.24

H-bond Donors 171.0

H-bond Acceptors 167.0

Rotatable Bonds 392.0

Heavy Atoms 870.0

Ring Count 25.0

Amide Bonds 117.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0246911 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is predicted to be either a homodimer or a heterodimer. Predicted interchain disulphide bond between cysteine residues at position 74 of each chain. Predicted N-linked glycosylation of asparagine residue at position 101; predicted disulphide bond formation between cysteine residues at positions 8 and 75, 37 and 107, and 41 and 109

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetGrowth/differentiation factor receptors (Human)