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MYP_152039
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Basic Information
Protegrin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C88H150N36O20S4
Standard
Sequence
RGGRLCYCRRRFCVCVGR
Physicochemical Analysis
2160.62 Da
10.66
5.72
5.46
0.3177
-0.25
0.39
-0.44
62.13
53.89
0.1111
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
949.65
-10.62
42.0
30.0
71.0
148.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076506 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Natural peptide
9823
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
6-15, 8-13
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium tuberculosis H37Rv
MIC
PMID15245864 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15245864/
RECORD: Rec_0081758 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Acinetobacter baumannii ATCC 379385
8 μg/mL
MIC
PMID31214759 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31214759/
RECORD: Rec_0085952 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-15, 8-13
Bio-Activity Profile
Other
PaperCationic antimicrobial peptides in clinical development, with special focus on thanatin and heliomicin.Eur J Clin Microbiol Infect Dis (2012) PMID21964560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21964560/
RECORD: Rec_0092010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
alpha helical peptide without cysteines
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
U-942
30-40 μg/mL
IC50
PMID21403917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21403917/
RECORD: Rec_0099162 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anti-inflammatory
B. anthracis
16 μg/mL
MIC
PaperSynthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity
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