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MYP_152039
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Basic Information
Protegrin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C88H150N36O20S4
Standard
Sequence
RGGRLCYCRRRFCVCVGR
Physicochemical Analysis
2160.62 Da
10.66
5.72
5.46
0.3177
-0.25
0.39
-0.44
62.13
53.89
0.1111
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
949.65
-10.62
42.0
30.0
71.0
148.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0377920 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
6-15, 8-13
6 - 15 and 8 - 13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
ATCC 700603
0.5 μg/mL
MIC
PMID35254120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35254120/
RECORD: Rec_0378168 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Acinetobacter baumannii ATCC 371981
4 μg/mL
MBC
PMID31214759 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31214759/
RECORD: Rec_0379283 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Natural peptide
9823
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
6-15, 8-13
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis E1380/94 MDR (Isoniazid, rifampicin, streptomycin, ethambutol) strain
50 μg/mL
MIC
PMID11328767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11328767/
RECORD: Rec_0383240 VERIFIED: YES
Provenance & Taxonomy
Alpha helical [Animal]; synthetic construct [Synthetic]
Designed peptide
33208; 32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID8335113 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8335113/
RECORD: Rec_0385517 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antifungal
Cryptococcus neoformans B3501
2, 4, 8 μM
XTT assay; Total countable CFUs
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