Peptide Database

Peptide NameSLAY-screened peptide P3676

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC78H120N20O20S2

DescriptionStandard

        PMNIIRCYPINWTT
    

Molecular Weight1722.04 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)0.95

Net Charge (pH 7.4) 0.87

Charge Density (pH 7.0) 0.0677

GRAVY Index-0.03

Hydrophobic Moment 0.36

Boman Index0.16

Instability Index25.96

Aliphatic Index 83.57

Aromaticity 0.1429

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 643.40

LogP -4.10

H-bond Donors 24.0

H-bond Acceptors 23.0

Rotatable Bonds 50.0

Heavy Atoms 120.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0004436 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/