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MYP_151921
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Basic Information
Defensin-A (Defensin A; Insects, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
43 amino acids
C184H299N59O56S6
Standard
Sequence
VTCDLLSFEAKGFAANHSICAAHCLAIGRKGGSCQNGVCVCRN
Physicochemical Analysis
4426.09 Da
8.34
1.85
1.45
0.0430
0.35
0.41
0.12
17.15
79.53
0.0465
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1846.60
-24.40
70.0
66.0
146.0
305.0
4.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283556 VERIFIED: YES
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-34, 20-39, 24-41
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
40 μM
MIC
PMID11719071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11719071/
RECORD: Rec_0394837 VERIFIED: NO
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal
Bacillus megaterium, Bacillus subtilis, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa
Qualitative functional evidence
PMID11719071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11719071/; https://www.uniprot.org/uniprotkb/P83669/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0408398 VERIFIED: YES
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-34, 20-39, 24-41
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterobacter asbriae
40 μM
MIC
PMID11719071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11719071/
RECORD: Rec_0416398 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 23.3%, E 18.6%, T 27.9%, C 30.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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