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MYP_151921
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Basic Information
Defensin-A (Defensin A; Insects, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
43 amino acids
C184H299N59O56S6
Standard
Sequence
VTCDLLSFEAKGFAANHSICAAHCLAIGRKGGSCQNGVCVCRN
Physicochemical Analysis
4426.09 Da
8.34
1.85
1.45
0.0430
0.35
0.41
0.12
17.15
79.53
0.0465
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1846.60
-24.40
70.0
66.0
146.0
305.0
4.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026857 VERIFIED: YES
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-34, 20-39, 24-41
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Serratia marcescens
40 μM
MIC
PMID11719071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11719071/
RECORD: Rec_0077993 VERIFIED: YES
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-34, 20-39, 24-41
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
2.5-5 μM
MIC
PMID11719071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11719071/
RECORD: Rec_0131166 VERIFIED: YES
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-34, 20-39, 24-41
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
1.2-2.5 μM
MIC
PMID11719071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11719071/
RECORD: Rec_0155435 VERIFIED: NO
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-34; 20-39; 24-41
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0160636 VERIFIED: YES
Provenance & Taxonomy
Anomala cuprea [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PaperInsect Biochem Mol Biol. 2001 Dec;32(1):75-84. | http://www.ncbi.nlm.nih.gov/pubmed/11719071 PMID11719071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11719071/
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