Peptide Database

Peptide NameMedusin-TR1 (MDS-TR1) (Phylloseptin-4TR) (PLS-4TR)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC84H151N19O22S

DescriptionStandard

        LLGMIPVAITAISALSKL
    

Molecular Weight1811.28 Da

Isoelectric Point (pI)8.75

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0422

GRAVY Index1.78

Hydrophobic Moment 0.39

Boman Index0.59

Instability Index13.83

Aliphatic Index 184.44

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 635.94

LogP -2.94

H-bond Donors 22.0

H-bond Acceptors 24.0

Rotatable Bonds 59.0

Heavy Atoms 126.0

Ring Count 1.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0120345 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans

Activity512 μg/mL

MethodMIC

RECORD: Rec_0138886 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEnterococcus faecalis

Activity512 μg/mL

MethodMIC

RECORD: Rec_0163710 VERIFIED: NO

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]; Phyllomedusa trinitatis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0163787 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

Activity64 μg/mL

MethodMIC

RECORD: Rec_0254124 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa trinitatis [Animal]

FamilyPhylloseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans

Activity100 μM

MethodMIC

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