Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length114 amino acids

Chemical FormulaC551H881N147O169S3

DescriptionStandard

        PDLSGYEKFGLGNVKYNISRIRVTAVEFPSASISLIPGTGIKLVIGNASLTIDMNWNIRTWMFKDSGRSTVYISKVFVTAIFSTPLDNTGHTSISLTSCRTTSGDTDIKLNGKS
    

Molecular Weight12364.97 Da

Isoelectric Point (pI)9.48

Net Charge (pH 7.0)4.04

Net Charge (pH 7.4) 3.89

Charge Density (pH 7.0) 0.0354

GRAVY Index-0.01

Hydrophobic Moment 0.53

Boman Index0.10

Instability Index13.00

Aliphatic Index 89.74

Aromaticity 0.0877

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5090.32

LogP -58.30

H-bond Donors 184.0

H-bond Acceptors 177.0

Rotatable Bonds 408.0

Heavy Atoms 870.0

Ring Count 17.0

Amide Bonds 120.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058007 VERIFIED: NO

Provenance & Taxonomy

OrganismSpheniscus mendiculus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence