Peptide Database

Peptide NameBNP(1-28)

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC119H204N38O38S4

DescriptionStandard

        SPKMVQGSGCFGRKMDRISSSSGLGCKV
    

Molecular Weight2903.38 Da

Isoelectric Point (pI)9.85

Net Charge (pH 7.0)3.44

Net Charge (pH 7.4) 3.20

Charge Density (pH 7.0) 0.1228

GRAVY Index-0.28

Hydrophobic Moment 0.71

Boman Index-0.08

Instability Index63.53

Aliphatic Index 48.57

Aromaticity 0.0357

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1243.86

LogP -18.23

H-bond Donors 47.0

H-bond Acceptors 46.0

Rotatable Bonds 101.0

Heavy Atoms 199.0

Ring Count 2.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0349053 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyNatriuretic peptide

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide10-26

Bio-Activity Profile

Function

Hormone Cardiovascular

RECORD: Rec_0354389 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyBNP(1-28)

Tax ID9606

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide10-26

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0418368 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 21.4%, E 7.1%, T 42.9%, C 28.6% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-Cell Communication