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MYP_151543
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Basic Information
Nigrosin-OG20 , nigrocin-2GRa , Grahamin-1, nigrosin-OG17, Grahamin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C84H149N23O25S2
Standard
Sequence
GLLSGILGAGKNIVCGLSGLC
Physicochemical Analysis
1945.35 Da
8.06
0.74
0.51
0.0352
1.31
0.44
0.50
23.45
148.57
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
754.89
-8.27
28.0
28.0
66.0
134.0
0.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0409737 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0412103 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Nigrocin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0413126 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Nigrocin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
50 μM
MIC
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0425234 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Refer PubMed 17272268 : - Escherichia coli
75.00 μg/mL
MIC
PMID17272268;16621155;16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
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