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MYP_151543
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Basic Information
Nigrosin-OG20 , nigrocin-2GRa , Grahamin-1, nigrosin-OG17, Grahamin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C84H149N23O25S2
Standard
Sequence
GLLSGILGAGKNIVCGLSGLC
Physicochemical Analysis
1945.35 Da
8.06
0.74
0.51
0.0352
1.31
0.44
0.50
23.45
148.57
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
754.89
-8.27
28.0
28.0
66.0
134.0
0.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0356081 VERIFIED: YES
Provenance & Taxonomy
Odorrana margaretae [Animal]
Nigrosin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
3.86 μM
MIC
PaperX. Xu et al. / Toxicon 47 (2006) 459-464. Two antimicrobial peptides from skin secretions of Rana grahami PMID16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16487561/
RECORD: Rec_0361920 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Refer PubMed 17272268 : - Escherichia coli
100 μg/mL
MIC
PMID17272268;16621155;16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
RECORD: Rec_0399760 VERIFIED: YES
Provenance & Taxonomy
Odorrana margaretae [Animal]
Nigrosin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
PaperX. Xu et al. / Toxicon 47 (2006) 459-464. Two antimicrobial peptides from skin secretions of Rana grahami PMID16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16487561/
RECORD: Rec_0402234 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Hemolytic activity
295 μM
LC50
PMID17272268;16621155;16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
RECORD: Rec_0407591 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Refer PubMed 17272268 : - Escherichia coli
25 μM
MIC
PMID17272268;16621155;16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
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