Peptide Database

Peptide NameSLAY-screened peptide P4234

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC110H153N29O29S3

DescriptionStandard

        CCTTWWNHCLLSHPFKNTSY
    

Molecular Weight2441.76 Da

Isoelectric Point (pI)7.97

Net Charge (pH 7.0)0.90

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0451

GRAVY Index-0.39

Hydrophobic Moment 0.32

Boman Index0.09

Instability Index30.52

Aliphatic Index 39.00

Aromaticity 0.2000

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 929.95

LogP -8.43

H-bond Donors 36.0

H-bond Acceptors 35.0

Rotatable Bonds 70.0

Heavy Atoms 171.0

Ring Count 9.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0041232 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/