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MYP_151443
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Basic Information
VG-Chol
Antimicrobial
Antiviral
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
46 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VALDPIDIANTISIVLNKAKSDLEESKEWIRRSNGKLDSIGSGSGX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011421 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-conjugated cysteine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Vero cells
>10000 nM
CC50
PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0016424 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-PEG24 conjugated cysteine
Bio-Activity Profile
Antimicrobial Antiviral
Nipah virus; Vero cells
~2 nM
IC90 (virus infection inhibition)
PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0124389 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-PEG24 conjugated cysteine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Vero cells
1.3 μM
CC50
PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0126761 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-conjugated cysteine
Bio-Activity Profile
Antimicrobial Antiviral
Human parainfluenza virus 3 (HPIV3); Vero cells
0.0007±0.00026 μM
IC90
PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0149965 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 42 indicates cholesterol-conjugated cysteine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Qualitative compound-level antiviral/cytotoxicity evidence
PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
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