Peptide Database

Peptide NameI16A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC132H220N50O27

DescriptionStandard

        FIHHIIGGLFSAGKAAHRLIRRRRR
    

Molecular Weight2939.48 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.02

Net Charge (pH 7.4) 6.66

Charge Density (pH 7.0) 0.2808

GRAVY Index-0.24

Hydrophobic Moment 0.90

Boman Index-0.19

Instability Index121.90

Aliphatic Index 105.60

Aromaticity 0.0800

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1265.41

LogP -10.65

H-bond Donors 49.0

H-bond Acceptors 37.0

Rotatable Bonds 100.0

Heavy Atoms 209.0

Ring Count 5.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0359130 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida albicans

Activity128 μg/mL

MethodMIC

PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/

RECORD: Rec_0390756 VERIFIED: YES