Peptide Database

Peptide NamepcrA signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Alkaline protease secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC156H262N44O51S3

DescriptionStandard

        MQDTIIERMLSELNPEQQKAVTHSNGPLLLMAG
    

Molecular Weight3666.21 Da

Isoelectric Point (pI)4.83

Net Charge (pH 7.0)-2.40

Net Charge (pH 7.4) -2.68

Charge Density (pH 7.0) -0.0728

GRAVY Index-0.26

Hydrophobic Moment 0.58

Boman Index0.04

Instability Index40.52

Aliphatic Index 97.58

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1539.11

LogP -15.81

H-bond Donors 50.0

H-bond Acceptors 53.0

Rotatable Bonds 125.0

Heavy Atoms 254.0

Ring Count 3.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0306460 VERIFIED: YES

Provenance & Taxonomy

OrganismShouchella clausii KSM-K16 [Bacterium]

FamilyTat signal peptide

Tax ID66692

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Alkalineprotease (alk) secretion

TargetBacillus amyloliquefaciens 111018

Activity8832.8 U/mL

MethodProtease activity assay

PaperLiu Y, Shi C, Li D, et al. Engineering a highly efficient expression system to produce BcaPRO protease in Bacillus subtilis by an optimized promoter and signal peptide[J]. International journal of biological macromolecules, 2019, 138: 903-911. PMID31356949 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31356949/