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MYP_151133
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Basic Information
HPA3NT3(Derived from HP (2-20))
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C104H163N27O17
Standard
Sequence
FKRLKKLFKKIWNWK
Physicochemical Analysis
2063.58 Da
11.43
6.75
6.54
0.4503
-1.03
0.91
-0.32
-4.64
78.00
0.2667
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
763.41
0.17
28.0
24.0
73.0
148.0
6.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0260404 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
S. typhimurium
2 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0272399 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
hRBCs
250 μM
Hemolysis
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0296654 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
A. parasiticus
8 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0310355 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
P. vulgaris
8 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0310959 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 19642077 PMID22982494;19642077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
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