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MYP_151133
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Basic Information
HPA3NT3(Derived from HP (2-20))
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C104H163N27O17
Standard
Sequence
FKRLKKLFKKIWNWK
Physicochemical Analysis
2063.58 Da
11.43
6.75
6.54
0.4503
-1.03
0.91
-0.32
-4.64
78.00
0.2667
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
763.41
0.17
28.0
24.0
73.0
148.0
6.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0189088 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
4 μM
MIC
PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 19642077 PMID22982494;19642077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0189141 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
A. fumigatus
4 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0202444 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
32 μM
MIC
PaperAntimicrobial peptide HPA3NT3-A2 effectively inhibits biofilm formation in mice infected with drug-resistant bacteria.
RECORD: Rec_0216099 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
T. beigelii
16 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0218270 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 19642077 PMID22982494;19642077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
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