Peptide Database

Peptide NameHPA3NT3(Derived from HP (2-20))

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC104H163N27O17

DescriptionStandard

        FKRLKKLFKKIWNWK
    

Molecular Weight2063.58 Da

Isoelectric Point (pI)11.43

Net Charge (pH 7.0)6.75

Net Charge (pH 7.4) 6.54

Charge Density (pH 7.0) 0.4503

GRAVY Index-1.03

Hydrophobic Moment 0.91

Boman Index-0.32

Instability Index-4.64

Aliphatic Index 78.00

Aromaticity 0.2667

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 763.41

LogP 0.17

H-bond Donors 28.0

H-bond Acceptors 24.0

Rotatable Bonds 73.0

Heavy Atoms 148.0

Ring Count 6.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0054065 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetListeria monocytogenes

Activity22 μM

MethodMIC

PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 19642077 PMID22982494;19642077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/

RECORD: Rec_0058951 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetSalmonella typhimurium

Activity2 μM

MethodMIC

PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 19642077 PMID22982494;19642077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/

RECORD: Rec_0080142 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetBacillus subtilis

Activity4 μM

MethodMIC

PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 19642077 PMID22982494;19642077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/

RECORD: Rec_0082150 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetEscherichia coli

Activity4 μM

MethodMIC

PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. | PubMed PMID: 19642077 PMID22982494;19642077 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/

RECORD: Rec_0089977 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

TargetEscherichia coli

Activity4 μM

MethodMIC

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