Peptide Database

Peptide NameO1-superfamily Conotoxin Leo-O1/O4

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC126H191N31O37S6

DescriptionStandard

        DCVKAGTACGFPKPEPACCSSWCIFVCT
    

Molecular Weight2924.44 Da

Isoelectric Point (pI)6.03

Net Charge (pH 7.0)-0.30

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0106

GRAVY Index0.52

Hydrophobic Moment 0.22

Boman Index0.23

Instability Index76.95

Aliphatic Index 45.36

Aromaticity 0.1071

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1046.00

LogP -11.18

H-bond Donors 41.0

H-bond Acceptors 43.0

Rotatable Bonds 85.0

Heavy Atoms 200.0

Ring Count 7.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0336943 VERIFIED: NO

Provenance & Taxonomy

OrganismConus leopardus [Animal]

FamilyConotoxin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-19; 9-23; 18-27

Bio-Activity Profile

Function

Toxin

RECORD: Rec_0409897 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 0.0%, T 57.1%, C 42.9% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic