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MYP_151115
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Basic Information
C(1-15)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C94H157N35O16
Standard
Sequence
RFGRFLRKIRRFRPK
Physicochemical Analysis
2033.48 Da
12.00
7.76
7.55
0.5172
-1.34
1.06
-0.77
67.54
52.00
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
885.37
-6.02
35.0
24.0
70.0
145.0
4.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0107582 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Salmonella Typhimurium NCTC 74
8 μg/mL
MIC
PaperDesign, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment.
RECORD: Rec_0198503 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli O175:H7
64 μg/mL
MIC
PaperDesign, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment.
RECORD: Rec_0258340 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Human serum: The antimicrobial activity of cyclic-C1-15 was lost after 3 h
PaperMolhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ. Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization. Peptides. 2011 May;32(5):875-80 PMID:21376095 https://pubmed.ncbi.nlm.nih.gov/21376095/ PMID21376095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21376095/
RECORD: Rec_0302913 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Toxic Hemolytic Immunomodulatory
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0337248 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Gram+ Staphylococcus aureus ATCC 9155
>128 μg/mL
MIC
PaperDesign, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment.
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