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MYP_151115
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Basic Information
C(1-15)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C94H157N35O16
Standard
Sequence
RFGRFLRKIRRFRPK
Physicochemical Analysis
2033.48 Da
12.00
7.76
7.55
0.5172
-1.34
1.06
-0.77
67.54
52.00
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
885.37
-6.02
35.0
24.0
70.0
145.0
4.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039209 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Cathelicidin
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli O78
16.7 ± 5.8 μM
MIC
PMID26848845 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26848845/
RECORD: Rec_0058042 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 9006174 B2 Evidence URLhttps://patents.google.com/patent/US9006174B2/en PatentUS 9006174 B2
RECORD: Rec_0067852 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Human serum: The antibacterial activity of C1-15 decreased substantially after incubation for 1 h in serum, with a complete abolishment after 2 h
PaperMolhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ. Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization. Peptides. 2011 May;32(5):875-80 PMID:21376095 https://pubmed.ncbi.nlm.nih.gov/21376095/ PMID21376095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21376095/
RECORD: Rec_0069470 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Immunomodulatory Antimicrobial
Chicken erythrocytes
40 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/19524300/ PMID19524300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19524300/
RECORD: Rec_0082530 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Amidation
D-Arg at 1st, 4th, 7th, 10th, 11th, and 13th position, D-Phe at 2nd, 5th, and 12th position, D-Gly at 3rd position, D-Leu at 6th position, D-Lys at 8th, and 15th position, D-Ile at 9th position, D-Pro at 14th position
Bio-Activity Profile
Antimicrobial Antibacterial
Human serum: the antibacterial activity of D-C1-15 was maintained up to 24 h incubation in serum
PaperMolhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ. Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization. Peptides. 2011 May;32(5):875-80 PMID:21376095 https://pubmed.ncbi.nlm.nih.gov/21376095/ PMID21376095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21376095/
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