Peptide Database

Peptide NameSLAY-screened peptide P5297

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H164N24O27S2

DescriptionStandard

        AHGHSLDLLYIIVMFALYCY
    

Molecular Weight2342.77 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-1.04

Net Charge (pH 7.4) -1.35

Charge Density (pH 7.0) -0.0521

GRAVY Index1.21

Hydrophobic Moment 0.25

Boman Index0.54

Instability Index-4.17

Aliphatic Index 141.50

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 791.80

LogP -0.62

H-bond Donors 29.0

H-bond Acceptors 30.0

Rotatable Bonds 71.0

Heavy Atoms 165.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0406260 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/