Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC312H469N77O94S4

DescriptionStandard

        MDNIAEIDYSLVNPPVITKTFMDLDFKGEFYNIGRHQEPPFTAGPLSFPEQTNHMMNLAVS
    

Molecular Weight6930.78 Da

Isoelectric Point (pI)4.49

Net Charge (pH 7.0)-5.31

Net Charge (pH 7.4) -5.65

Charge Density (pH 7.0) -0.0871

GRAVY Index-0.28

Hydrophobic Moment 0.54

Boman Index0.11

Instability Index56.30

Aliphatic Index 70.33

Aromaticity 0.1148

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2709.98

LogP -23.84

H-bond Donors 87.0

H-bond Acceptors 95.0

Rotatable Bonds 219.0

Heavy Atoms 487.0

Ring Count 15.0

Amide Bonds 67.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040295 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinchus milii [Animal]

FamilyBPI

Tax ID7868

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence