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MYP_151072
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Basic Information
KR-12-a2 (Derived from KR-12)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
12 amino acids
C75H134N26O14
Standard
Sequence
KRIVQRIKKWLR
Physicochemical Analysis
1624.03 Da
12.00
5.76
5.55
0.4798
-1.05
1.00
-0.60
48.52
121.67
0.0833
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
706.06
-3.31
27.0
20.0
59.0
115.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0048826 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-inflammatory
Pseudomonas aeruginosa KCTC 1637
8 μM
MIC
PaperShort KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity.
RECORD: Rec_0048940 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli gsk12
1.17±0.83 μM
MIC
PMID35203875 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35203875/
RECORD: Rec_0076896 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Acinetobacter baumannii 1757
2.53±1.02 μM
MIC
PMID35203875 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35203875/
RECORD: Rec_0077342 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae 613
23.74±29.65 μM
MIC
PMID35203875 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35203875/
RECORD: Rec_0095049 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa (KCTC 1637)
8 μM
MIC
PaperShort KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity. J Pept Sci. 2013 Nov;19(11):700-7. doi: 10.1002/psc.2552. PMID: 24105706. PMID24105706 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24105706/
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