Peptide Database

Peptide NameNPP 2

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC333H526N94O120S3

DescriptionStandard

        QCWDSSHCKDLPSEDKILECIHLFRSGLQDESPEPRSAAQQSTEESLSLGILLAALTSGERALDADPEPHSD
    

Molecular Weight7862.49 Da

Isoelectric Point (pI)4.39

Net Charge (pH 7.0)-9.98

Net Charge (pH 7.4) -10.40

Charge Density (pH 7.0) -0.1386

GRAVY Index-0.63

Hydrophobic Moment 0.52

Boman Index-0.09

Instability Index91.53

Aliphatic Index 78.75

Aromaticity 0.0278

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3419.89

LogP -41.36

H-bond Donors 118.0

H-bond Acceptors 116.0

Rotatable Bonds 260.0

Heavy Atoms 550.0

Ring Count 11.0

Amide Bonds 75.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0278041 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyPOMC

Tax ID8022

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor

RECORD: Rec_0363577 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyNPP

Tax ID8022

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0402734 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/