Peptide Database

Peptide NameSLAY-screened peptide P1337

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H164N36O27

DescriptionStandard

        LPHNIWHRTGLLTHNWTARS
    

Molecular Weight2410.69 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.02

Net Charge (pH 7.4) 1.67

Charge Density (pH 7.0) 0.1011

GRAVY Index-0.73

Hydrophobic Moment 0.28

Boman Index-0.04

Instability Index81.64

Aliphatic Index 83.00

Aromaticity 0.1000

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1015.95

LogP -9.29

H-bond Donors 37.0

H-bond Acceptors 32.0

Rotatable Bonds 72.0

Heavy Atoms 172.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0351886 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/