Peptide Database

Peptide NameSLAY-screened peptide P5269

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC52H79N17O14S

DescriptionStandard

        QGCLHPPRGAY
    

Molecular Weight1198.35 Da

Isoelectric Point (pI)8.23

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.57

Charge Density (pH 7.0) 0.0760

GRAVY Index-0.76

Hydrophobic Moment 0.36

Boman Index-0.03

Instability Index19.20

Aliphatic Index 44.55

Aromaticity 0.0909

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 490.64

LogP -5.04

H-bond Donors 17.0

H-bond Acceptors 17.0

Rotatable Bonds 33.0

Heavy Atoms 84.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0195874 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/