Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length485 amino acids

Chemical FormulaC2421H3855N633O677S13

DescriptionStandard

        TKMAREPDSALRWAGLLVLTTLSTAVIATTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPEFSGSFKVKHLGKGHYRFYSMVIRGFQLPSSHIKLVPEKGLDLSISNANIKISGKWKARKKFIKTSGNFDLSVEGISISAGLQLGFDPSSGLPTATCSSCSNQINAVHVHISGSKLGWLIQLFHKKIESSIRKTMESKICQVVTSSVSSKLQSYLKTLRVTTKIDKVAGINYSLVAPPTTTADNLDGQLKGEFFSVAHPSPPPFAPPVLAFPADHNRMVYLELSDYFFNTAGFVYQQAGALHLTVTDNMIPKGSKFRLTTTFFGVLIPQVAKMFPNMTMQLNIRAPSPPHLTVLPTGLVFTPVLETQAFAVLPNSSLAPLFVLQLSTNFSVEVGTTPDRLIGKLRLNRLLLELKHSDVGPFSVTELQAVMNYLLPTIVIPKVNERLQEGFPLPLPADVQLSNLVLQTHQNFLLFGADVHYG
    

Molecular Weight53078.19 Da

Isoelectric Point (pI)9.59

Net Charge (pH 7.0)16.51

Net Charge (pH 7.4) 15.51

Charge Density (pH 7.0) 0.0340

GRAVY Index0.10

Hydrophobic Moment 0.76

Boman Index0.14

Instability Index37.59

Aliphatic Index 100.27

Aromaticity 0.0825

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0104733 VERIFIED: NO

Provenance & Taxonomy

OrganismNeovison vison [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence