Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length178 amino acids

Chemical FormulaC897H1430N246O238S10

DescriptionStandard

        PMTPPMAPEPMLMLAVTEFVANSAAFTYFTAGALRRNISSDMLPRRFPLQLRTKSMEVFSPQLQELYPDRPMELHLWARQQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLGLPVPQVKRLETLLKFALWLFGVPRANSKCCPRPVP
    

Molecular Weight19789.11 Da

Isoelectric Point (pI)10.13

Net Charge (pH 7.0)8.21

Net Charge (pH 7.4) 7.93

Charge Density (pH 7.0) 0.0461

GRAVY Index0.04

Hydrophobic Moment 0.57

Boman Index0.08

Instability Index59.75

Aliphatic Index 92.08

Aromaticity 0.0787

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7594.54

LogP -81.78

H-bond Donors 262.0

H-bond Acceptors 259.0

Rotatable Bonds 622.0

Heavy Atoms 1391.0

Ring Count 40.0

Amide Bonds 190.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419445 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptocoma aspasia [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria