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MYP_150879
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Basic Information
Chemokinostatin-6
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
24 amino acids
C121H203N31O35S
Standard
Sequence
NGKQVCLDPEAPFLKKVIQKILDS
Physicochemical Analysis
2684.16 Da
8.16
0.75
0.52
0.0313
-0.21
0.74
-0.01
43.25
109.58
0.0417
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1080.52
-8.34
35.0
37.0
92.0
188.0
3.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038173 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Structure & Mods
linear peptide; DSSP H 16.7%, E 0.0%, T 41.7%, C 41.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Anti-angiogenic
Human endothelial cells
Endothelial-cell proliferation and migration inhibition assays
PaperNovel anti-angiogenic peptides derived from ELR-containing CXC chemokines PMID26335203;18307172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26335203/
RECORD: Rec_0049277 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Chemokinostatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic Anticancer
Human endothelial cells
Endothelial-cell proliferation and migration inhibition assays
PaperSupporting Information for Karagiannis and Popel, PNAS (10.1073/pnas.0803241105) PMID18780781;18307172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18780781/
RECORD: Rec_0052424 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer Anti-angiogenic
Human endothelial cells
Endothelial-cell proliferation and migration inhibition assays
PaperNovel anti-angiogenic peptides derived from ELR-containing CXC chemokines PMID18307172
RECORD: Rec_0104314 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Chemokinostatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-angiogenic Anticancer
Human endothelial cells
Endothelial-cell proliferation and migration inhibition assays
PaperNovel anti-angiogenic peptides derived from ELR-containing CXC chemokines PMID18307172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18307172/