Peptide Database

Peptide NameProgonadoliberin-2

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length84 amino acids

Chemical FormulaC429H645N123O121S

DescriptionStandard

        QHWSHGWYPGGKRSPDSPQDPQPAPRFPEGYWLGLAAGNPRQSTQSLPSKALAPPEDTVSEEAKTMAWWHLQKQRLIQTLLPRP
    

Molecular Weight9493.53 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)2.03

Net Charge (pH 7.4) 1.66

Charge Density (pH 7.0) 0.0242

GRAVY Index-1.02

Hydrophobic Moment 0.56

Boman Index-0.10

Instability Index91.31

Aliphatic Index 53.57

Aromaticity 0.0952

Extinction Coeff. Reduced 30480.00

Extinction Coeff. Oxidized 30480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3854.82

LogP -38.19

H-bond Donors 128.0

H-bond Acceptors 127.0

Rotatable Bonds 289.0

Heavy Atoms 674.0

Ring Count 29.0

Amide Bonds 92.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034843 VERIFIED: NO

Provenance & Taxonomy

OrganismSuncus murinus [Animal]

FamilyGnRH

Tax ID9378

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsGly10 Amidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0109807 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0216978 VERIFIED: NO

Provenance & Taxonomy

OrganismSuncus murinus [Animal]

FamilyProgonadoliberin

Tax ID9378

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods10:Glycine amide

Bio-Activity Profile

Function

Hormone Endocrine Reproductive regulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour