Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2400H3824N620O661S15

DescriptionStandard

        DKGEKMLKVWYSFLLCWLSLQLEANPGLKVRITQKGLDYGRRIAMELLKQAVLKETFPSWSGQESFLVIKANYVISRLRINALDFPETSASFIPGTGISLSIAHASATISADWRMNAWLLKDEGGITVSISGAFIAVIFKVSRDSTGRFSILLHNCQLSINGIKVKLNGGSSWIYSFLSGYLEKPIHTKLNKNLCLNIKHKIKMMDEQLRRHKVLRQIDAFAQIDYSLISSPAVFKSHINLDLKGTVYPVGNHTDPPFVPAPFALPNQGDSMLYLGVSSYFLKSASLAYYRAGAFNITISDELATTFNLNTALFKDFIPKISLSYLTACPVLLKLMATSPPAVSLNADRCLLQIIGCVEVFAVLPNSTTQYIFSGNLTASTRANLTITKQKLILSLLLKRLQFSLLHSTLRFSEMSLVENFLSYALQSAVIPVINDKLGKGLPLLNLAHTILTGPVIKMNQGHLVISTDVHYK
    

Molecular Weight52420.77 Da

Isoelectric Point (pI)9.55

Net Charge (pH 7.0)18.67

Net Charge (pH 7.4) 17.72

Charge Density (pH 7.0) 0.0395

GRAVY Index0.22

Hydrophobic Moment 0.73

Boman Index0.16

Instability Index35.44

Aliphatic Index 111.35

Aromaticity 0.0930

Extinction Coeff. Reduced 55350.00

Extinction Coeff. Oxidized 55725.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0350958 VERIFIED: NO

Provenance & Taxonomy

OrganismEgretta garzetta [Animal]

FamilyBPI/LBP

Tax ID188379

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria