Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2336H3732N590O676S17

DescriptionStandard

        MFLWCVLVLLNLVSVATGTNAGVKVRLTQKGLEYGRQIGIASIQQKLRTIKVPDISGTEKVDPIGKVQYSFTGMQIVNLGLPKSALVLVPDTGVMLSIGNAYINLHGNWRVKYLRIIKDSGSFDLAVSELTISTTVAVMSDDTGHPTVSMTNCAATVGSVNVKFHGGASWLYNLFSSFINKALRNALQKQICPLVADSIADINPHLKTLNVLAKVDQYAEIEYSMVGSPVISNTSIDLGLKGEFYNIGQHKEPPFSPTPFSLPSQDTDMLYIGVSAFTINSAGFVYNRAGALSLYITDDMIPSGSPIRLNTKTFGAFIPQIEKMYPGLMMKLLVETVKEPIVTFEPNNMTVQASSTVTAYAIQPNSTLSPLFVLNLEVSVSTHIYVTELKLAGNVTLNKINMSLAKSYVGPFQVTSLDNIFTIVLKFAVIPKVNARLQEGYPLPAIGKMQLVNSQLKVLKDYLLIGTDVQFTG
    

Molecular Weight51443.27 Da

Isoelectric Point (pI)8.82

Net Charge (pH 7.0)5.01

Net Charge (pH 7.4) 4.34

Charge Density (pH 7.0) 0.0106

GRAVY Index0.24

Hydrophobic Moment 0.72

Boman Index0.19

Instability Index28.94

Aliphatic Index 106.89

Aromaticity 0.0825

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 41955.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340563 VERIFIED: NO

Provenance & Taxonomy

OrganismCyprinus carpio [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence