Peptide Database

Peptide NameAvalglucosidase alfa

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length896 amino acids

Chemical FormulaC4490H6829N1197O1298S32

DescriptionStandard

        QQGASRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGAQMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTIKDPANRRYEVPLETPRVHSRAPSPLYSVEFSEEPFGVIVHRQLDGRVLLNTTVAPLFFADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLALEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDGFRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELENPPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVRWTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAGETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPIEALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQPMALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQLQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
    

Molecular Weight99370.57 Da

Isoelectric Point (pI)5.46

Net Charge (pH 7.0)-22.15

Net Charge (pH 7.4) -23.93

Charge Density (pH 7.0) -0.0247

GRAVY Index-0.17

Hydrophobic Moment 0.76

Boman Index0.10

Instability Index44.95

Aliphatic Index 81.63

Aromaticity 0.1060

Extinction Coeff. Reduced 161690.00

Extinction Coeff. Oxidized 162440.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0135371 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyEnzyme

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPhosphorylation

Bio-Activity Profile

Function

Enzyme replacement

Half-LifeThe mean avalglucosidase alfa-ngpt plasma elimination half-life was 1.6 hours in patients with late-onset Pompe disease.[L35155]