Peptide Database

Peptide NameSLAY-screened peptide P3720

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H159N37O26S3

DescriptionStandard

        PFTRNHGPRCLRLRDFCSCH
    

Molecular Weight2415.78 Da

Isoelectric Point (pI)9.36

Net Charge (pH 7.0)3.10

Net Charge (pH 7.4) 2.90

Charge Density (pH 7.0) 0.1552

GRAVY Index-0.79

Hydrophobic Moment 0.52

Boman Index-0.34

Instability Index74.06

Aliphatic Index 39.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1019.25

LogP -11.75

H-bond Donors 41.0

H-bond Acceptors 34.0

Rotatable Bonds 75.0

Heavy Atoms 168.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0139193 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/