Peptide Database

Peptide NameE1P44-1

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC109H157N23O29

DescriptionStandard

        TEQLASNYWILEYLWKVP
    

Molecular Weight2253.55 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.80

Charge Density (pH 7.0) -0.0888

GRAVY Index-0.19

Hydrophobic Moment 0.41

Boman Index0.20

Instability Index54.92

Aliphatic Index 108.33

Aromaticity 0.2222

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 848.53

LogP -2.28

H-bond Donors 29.0

H-bond Acceptors 28.0

Rotatable Bonds 68.0

Heavy Atoms 161.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0149360 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAurein

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3; TZM-bl cells; gp41

Activity>125 μM

MethodHIV-1 infection and Env-mediated cell-fusion inhibition (IC50/FRET)