Peptide Database

Peptide NameE1P41

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC112H153N27O31

DescriptionStandard

        LKWESEFWRWTEQLASNY
    

Molecular Weight2373.58 Da

Isoelectric Point (pI)4.79

Net Charge (pH 7.0)-1.23

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.0685

GRAVY Index-1.11

Hydrophobic Moment 0.60

Boman Index-0.09

Instability Index71.00

Aliphatic Index 48.89

Aromaticity 0.2778

Extinction Coeff. Reduced 17990.00

Extinction Coeff. Oxidized 17990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 972.31

LogP -5.39

H-bond Donors 35.0

H-bond Acceptors 30.0

Rotatable Bonds 74.0

Heavy Atoms 170.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0001402 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAurein

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3; TZM-bl cells; gp41

Activity>125 μM

MethodHIV-1 infection and Env-mediated cell-fusion inhibition (IC50/FRET)