Peptide Database

Peptide NameSLAY-screened peptide P5901

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H151N21O26S2

DescriptionStandard

        WCVPVFGFATYSIYCLPFSA
    

Molecular Weight2271.65 Da

Isoelectric Point (pI)5.51

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.50

Charge Density (pH 7.0) -0.0131

GRAVY Index1.22

Hydrophobic Moment 0.18

Boman Index0.58

Instability Index53.88

Aliphatic Index 78.00

Aromaticity 0.3000

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 715.58

LogP -1.73

H-bond Donors 27.0

H-bond Acceptors 28.0

Rotatable Bonds 60.0

Heavy Atoms 161.0

Ring Count 9.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0174913 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/