Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 16.8

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC169H270N54O53S6

DescriptionStandard

        GLIDVKCYASRECWEPCRKVTGSGQAKCQNNQCRCY
    

Molecular Weight4098.67 Da

Isoelectric Point (pI)8.65

Net Charge (pH 7.0)2.70

Net Charge (pH 7.4) 2.40

Charge Density (pH 7.0) 0.0751

GRAVY Index-0.74

Hydrophobic Moment 0.67

Boman Index-0.24

Instability Index29.53

Aliphatic Index 43.33

Aromaticity 0.0833

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1781.08

LogP -22.30

H-bond Donors 68.0

H-bond Acceptors 62.0

Rotatable Bonds 136.0

Heavy Atoms 282.0

Ring Count 5.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086766 VERIFIED: YES

Provenance & Taxonomy

OrganismButhus occitanus [Animal]

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-28, 13-33, 17-35

Bio-Activity Profile

Function

Toxin

TargetI-kaliotoxin binding on rat brain synaptosome

Activity0.1 μM

MethodIC50