Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length509 amino acids

Chemical FormulaC2558H4068N664O711S19

DescriptionStandard

        MARGPDTARRWATLVVLAALGTAVTTTNPGIVARITQKGLDYACQQGVLTLQKELEKITIPNFSGNFKIKYLGKGQYSFFSMVIQGFNIPNSQIRPLPDKGLDLSIRDASIKIRGKWKARKNFIKLGGNFDLSVEGISILAGLNLGYDPASGHSTVTCSSCSSGINTVRIHISGSSLGWLIQLFRKRIESLLQKSMTRKICEVVTSTVSSKLQPYFQTLPVTTKLDKVAGVDYSLVAPPRATANNLDWLLKGEFFSLAHRSPPPFAPPALAFPSDHDRMVYLGISEYFFNTAGFVYQKAGALNLTLRDDMIPKESKFRLTTKFFGILIPQVAKMFPDMQMQLFIWASLPPKLTMKPSGLDLIFVLDTQAFAILPNSSLDPLFLLEMNLNLSVVVGAKSDRLIGELRLDKLLLELKHSDIGPFSVESLQSVINYVMPTIVLPVINKKLQKGFPLPLPAYIELFNLTLQPYQMSTTAEDPMGAGGRQSGGYCPHMRPVLTSEKNPQLSAFA
    

Molecular Weight56108.92 Da

Isoelectric Point (pI)9.55

Net Charge (pH 7.0)16.99

Net Charge (pH 7.4) 16.29

Charge Density (pH 7.0) 0.0334

GRAVY Index0.06

Hydrophobic Moment 0.69

Boman Index0.12

Instability Index36.01

Aliphatic Index 98.86

Aromaticity 0.0904

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0065433 VERIFIED: NO

Provenance & Taxonomy

OrganismBos mutus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria